Join 200+ Companies Innovating in St. Louis
CIC St. Louis is home to over 200 organizations, ranging from a variety of industries. By locating here, you work alongside the visionaries shaping the future of innovation.
Grow your business in the Cortex Innovation District
Cortex is more than just a place to rent an office—it’s a purpose-built neighborhood designed for discovery and growth. As a cornerstone of the district, CIC St. Louis connects you to a vibrant community of entrepreneurs, researchers, and global companies across 200 acres in the city’s central corridor.
Reach world-class institutions and amenities in minutes
CIC St. Louis is a 10-minute walk from WashU Medical Center and Shriner’s Children’s, and just 15 minutes from Saint Louis University and City Foundry STL.
This density makes it easy to tap into the talent and energy of the district.
Commute via Cortex MetroLink Station and I-64
Getting here is easy for your team and clients. The dedicated Cortex MetroLink Station connects the district directly to St. Louis Lambert International Airport and Downtown. Immediate access to I-64 and on-site parking ensure your commute is friction-free.
Why St. Louis’s Top Innovators Choose CIC
By choosing CIC St. Louis, you trade the restraints of a traditional lease for an agile, globally connected workspace.
Access Global Hubs from Cambridge to Tokyo
Your membership in St. Louis unlocks the world through our Global Passport program. Gain seamless access to workspace in key innovation markets, including Cambridge, Rotterdam, and Warsaw.
Scale Operations with Flexible 30-Day Terms
Unlike static 5-year commercial leases that trap capital, our 30-day rolling membership allows you to expand from a single coworking desk to a full private suite This agility is critical for startups navigating the volatility of early-stage growth.
Experience the Energy of St. Louis Innovation
Our campus blends St. Louis’s industrial character with modern, award-winning design. You can settle into the historic feel of the former Dorris Motor Car factory at 20 South Sarah Street or work from LEED Platinum-certified 4240 Duncan building, which features a central atrium flooded with natural light.
Utilize CIC Campus amenities to support your workday
Your membership covers more than just a desk or office space. We provide the full-service infrastructure required to run your business, including unmetered conference rooms, enterprise-grade WiFi, and fully stocked kitchens.
Unmetered Conference Rooms
Fully
Stocked Kitchens
Dedicated
On-Site
Staff
Prestigious
Mailing
Address
Secure
High-Speed Internet
Building
Access
24/7
Printing
& Copy
Included
Community Events & Networking
Game Room
& Chill-Out
Lounges
Underground
Parking
Option
Mail &
Packaging
Services
Access
to All CIC
Locations
Professional Workspace and Member Services
Our St. Louis campus is designed for maximum operational flexibility, offering a professional home base that balances high-intensity work with essential employee wellness facilities.
Highlights of the St. Louis Campus
Record in the Professional Podcast Studio
Establish your brand’s media presence without leaving the office. Our fully soundproofed, bookable Podcast Studio is equipped with professional-grade hardware for high-quality audio production.
Refresh in On-site Showers and Wellness Rooms
Support your team’s well-being with dedicated spaces for recovery and personal care. Our private showers and wellness rooms are available 24/7.
24/7 Campus Building Access
Members have around-the-clock access to all three campus buildings, ensuring that secure workspaces, high-speed internet, and utilities are always available for late-night R&D or global coordination across time zones.
Specialized Lab Infrastructure and Equipment
CIC St. Louis provides turnkey, BSL-2 compliant wet lab spaces designed to bridge the gap between discovery and commercialization. Our membership includes immediate access to state-of-the-art core instrumentation, personal protective equipment (PPE), and comprehensive technical training.
Our shared labs are outfitted with the hardware required for rigorous biological and chemical research. This inventory allows startups to begin operating immediately without capital-heavy equipment purchases.
Labs Amenities and Managed Operations
Our Lab Operations Team manages the logistics and safety protocols to ensure a compliant research environment. It includes biohazardous waste removal, equipment maintenance, safety checks, and so much more.
Secure Your Workspace in the Cortex Innovation District in Three Steps
Bypass the complexity of traditional commercial real estate. Our streamlined onboarding process is designed to get your team operational within the Cortex Innovation Community without long-term liability.
Come see the campus in person. A tour is the best way to see our buildings, check out the specialized equipment, and find the workspace that fits your team’s daily rhythm.
Choose a configuration that fits your current headcount and technical needs. Whether you require a private suite with custom branding or a lab space with specialized needs our operations team handles the logistics, furniture, and IT provisioning before you arrive.
We replace complex multi-year leases with transparent, 30-day terms. Gain immediate access to your workspace, amenities, and the global CIC network.
Networking events and community programming
Our campus is built to help you move beyond traditional networking and build genuine relationships through high-impact programming. From community breakfasts to curated sessions with local partners, we provide the space and structure for you to solve problems alongside other innovators in the district.
Growth Stories from the St. Louis Community
By providing infrastructure that scales with the business, we enable members to focus entirely on their company rather than their lease.
“We started out in this lab, and I just kept hiring, and hiring, and hiring. Soon, we needed more space. First, an office down the hall for quiet calls, then an office in the other CIC building for when I need some focus time. And now we’re starting to think about where we go from here.”
Tom Cirrito
PhD, CEO
“Our last office had zero amenities, so someone was always stuck playing janitor. Now, CIC takes care of all that: print centers for pitches, phone booths for calls, no dish duty at day’s end. CIC’s setup cuts the noise so we can build, sell, and grow without tripping over logistics.”
Stephen Seaman
Founder, COO
“I value the diversity of the companies and organizations represented in the CIC community, and I love running into people I know on a daily basis. I appreciate how the CIC team takes care of The Rome Group and all of the members here. They remove the friction so that we can focus on the work.”
Dayna Stock
CEO
Frequently Asked Questions about Our St. Louis Campus
Get answers to common questions about logistics, lab safety, and membership terms before you schedule your visit.
There are multiple parking options for members and guests. Secured garage parking is available adjacent to the 4240 and 4220 buildings, with visitor validation options. For cyclists, we provide indoor, secure bike storage rooms and showers to support your commute via the Cortex trails.
Our labs are built for Biosafety Level 2 (BSL-2) research. We provide the technical environment you need for biological and chemical work, equipped with biosafety cabinets, fume hoods, and autoclaves. We handle the heavy lifting—like hazardous waste removal and safety compliance—so your team can move in and start experiments immediately.
Yes. All members receive 24/7 keycard access to their specific building as well as campus-wide access to communal areas and coworking lounges.
We provide enterprise-grade internet with a dedicated ISP backbone, ensuring high uptime and symmetrical speeds suitable for large datasets and cloud computing. Members can also request private VLANs and dedicated IP addresses for enhanced security.
Yes. Membership includes a professional mailing address at either 4240 Duncan, 4220 Duncan, or 20 S Sarah St, depending on your base. Our community team handles mail and package sorting daily.
Your guests are welcome during business hours. They simply check in with our concierge team at the front desk, who will notify you of their arrival. For larger meetings, you can book conference rooms that are easily accessible to external visitors.
Explore CIC Locations Worldwide
Access our global network of innovation campuses across North America, Europe, and Asia. Select a city below to discover our workspaces and labs in major international hubs.
BERLIN
CAMBRIDGE
FUKUOKA
PROVIDENCE
BOSTON
ROTTERDAM
PHILADELPHIA
TOKYO
WARSAW
Read the Latest Insights from Our Community
Dive into stories about member breakthroughs, interviews with St. Louis founders, and analysis of the trends shaping the future of innovation.
Innovation Hub "O-Nexus," Operated by Nippon Life and CIC, Opens
Collective Impact in Action: CIC at Venture Café Global Gathering 2026
What happens when hundreds of innovators come together in one place? Ideas accelerate, connections deepen, and collective impact takes shape.
CIC and BAT formalize a strategic partnership to shape and deliver innovation led spaces worldwide
Visit CIC St. Louis
CIC St. Louis
4220 Duncan Ave., St. Louis, MO 63110
Tel: +1 (314) 332-2027
4220 Duncan Ave., St. Louis, MO 63110
Tel: +1 (314) 236-9010
20 S Sarah St., St. Louis, MO 63108
Tel: +1 (314) 615-6300
4 minute walk from Cortex Station Metrolink | 3-5 minute drive from major highways | 20 minute drive from St. Louis Lambert International Airport
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